He was born in 1994 in Kherson in the family of the musicians. He began learning to play violin at the age of 4. When he turned 8 Roman won The Beethoven's National Competition (Kharkiv, Ukraine). At age of 11, he played his first solo concert. In 2010 Roman entered Mykola Lysenko Specialized Music Boarding School in Kyiv. In 2012 Roman entered The Tchaikovsky National Music Academy of Ukraine (class of Serhiy Shott).
During his studies at the music school Roman became the laureate of regional, national and international competitions. While studying at the Academy, he takes part in many concerts as a soloist. In 2013 Roman Kholmatov became the finalist and the special prize winner on the 1st Oleh Krysa International Violin Competition (Lviv). In July 2018 Roman won 3rd Prize at the Eugene Ysaye International Violin Competition (Belgium). In November 2018 Roman won 1st Prize at the V Mirecourt International Violin Competition (France) and Prix des eleves de l’ecole de luthiere.
Starting 2018 Roman performs as a soloist with National Chamber Orchestra "Kyiv Camerata". Roman Kholmatov currently performs on the 1807 "Mon Senior" Joseph Klotz violin.